ABSTRACT
Introduction: COVID-19 vaccine have been indicated to successfully decrease the hazard for symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection furthermore associated hospitalisations. Objective: To study the immune response among different types of SARS-CoV-2 vaccines. Methods: This study includes 100 vaccinated individuals (43 Sinopharm, 30 AstraZeneca and 27 Pfizer) with one or two doses from different health centres in Baghdad. During the period from April 2021 to the end of May 2021, SARS-CoV-2 IgG and SARS-CoV-2 IgM levels were detected using AFIAS-6 device depending on FIA (Fluorescence Immunoassay) technique. Results: 93% of the cases were positive for IgG levels, and negative in 7% cases. Coronavirus IgM concentrations for all individuals were negative. The highest IgG mean level was seen in vaccinated persons with Pfizer than AstraZeneca (34.41, 26.29 respectively) and the lowest mean value was detected in Sinopharm (23.76). There was a significant elevation in IgG levels in the previously infected group in comparison with non-infected individuals. IgG levels decrease in antibody responses to SARS-CoV-2 in older individuals compared to younger participants. Also, results reported that SARS-CoV-2 IgG levels increased in males who were vaccinated with Pfizer and AstraZeneca more than females, while there is a significant decrease in IgG levels in vaccinated males with Sinopharm as compared to females. Conclusion: Different vaccines against SARS-CoV-2 produce different levels of IgG. Copyright (c) 2022: Author(s).
ABSTRACT
Novel coronavirus the global worldwide health problem that infects the upper and lower part of respiratory tract started in December, 2019 in Wuhan, China. Correlation between immunoglobulin levels and laboratory parameters helps in the diagnosis of covid-19 and its severity. Eighty-three individuals were enrolled in the study, 59 of them diagnosed as infected patients, and the other 24 participants were healthy control. Laboratory test and levels of IgM and IgG was done for both groups. Patients showing a significant increase in the levels of D-dimer, Ferritin, LDH and CRP (p-value: 0.0018, 0.0001, 0.0001 and 0.0007, respectively) and a significant decrease in the erythrocytes count and lymphocytes (0.0001 and 0.0097 respectively). There is no significant difference between patients and healthy individuals in leukocytes count, neutrophils count, and platelets (PLTs) count. Also, there is a high significant correlation between the concentration of IgM and all laboratory findings, and an expressive correlation between IgG levels and D-Dimer, Ferritin, LDH and Neutrophil count only. There is a highly significant interconnection between the age of patients and levels of IgM and IgG. This study concluded that the routine laboratory tests may be used early as a parameter of the severity of infection, detection of IgM and IgG levels could play a significant role in the covid-19 prognosis and diagnosis. There is a close relation between the laboratory assay and immunoglobulin state in infected patients.
ABSTRACT
The outbreak of the coronavirus disease 2019 (Covid-19) pandemic not only has created a health crisis across the world but is also expected to impact negatively the global economy and societies at a scale that is maybe larger than that of the 2008 financial crisis. Simultaneously, it has inevitably exerted many negative consequences on the geoenvironment on which human beings depend. The current paper articulates the role of environmental geotechnics in elucidating and mitigating the effects of the current pandemic. It is the belief of all authors that the Covid-19 pandemic presents not only significant challenges but also opportunities for the development of the environmental geotechnics field. This discipline should make full use of geoenvironmental researchers' and engineers' professional skills and expertise to look for development opportunities from this crisis, to highlight the irreplaceable position of the discipline in the global fight against pandemics and to contribute to the health and prosperity of communities, to serve humankind better. In order to reach this goal while taking into account the specificity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the uncertainty of its environmental effects, it is believed that more emphasis should be placed on the following research directions: pathogen-soil interactions;isolation and remediation technologies for pathogen-contaminated sites;new materials for pathogen-contaminated soil;recycling and safe disposal of medical wastes;quantification of uncertainty in geoenvironmental and epidemiological problems;emerging technologies and adaptation strategies in civil, geotechnical and geoenvironmental infrastructures;pandemic-induced environmental risk management;and modelling of pathogen transport and fate in geoenvironment, among others. Moreover, Covid-19 has made it clear to the environmental geotechnics community the importance of urgent international co-operation and of multidisciplinary research actions that must extend to a broad range of scientific fields, including medical and public health disciplines, in order to meet the complexities posed by the Covid-19 pandemic. © 2021 ICE Publishing: All rights reserved.
ABSTRACT
The pandemic of coronavirus disease (COVID)-2019 has been affected many people all around the world. Patients with mental disorders are not as safe as others;also, they might be more vulnerable in such situations. These patients take various medications, which can lead to numerous drug-drug interactions with experimental drugs uses against COVID-19. According to the potential critical interactions, we reviewed the reputable databases to find the interactions between main categories of psychiatric medications (e.g., antidepressants, anti-psychotics, sedative/hypnotics, and mood stabilizers) when used in concomitant with COVID-19 experimental agents (e.g., hydroxychloroquine, lopinavir/ritonavir, atazanavir, and chloroquine). We hope the list provided in this review helps the clinical care staff in treating patients with mental illness infected with severe acute respiratory syndrome coronavirus 2 during the COVID-19 pandemic.
ABSTRACT
Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body;it is also utilized to decreasing the chances of breast cancer developing in high-risk patients. Recently, some studies focused on the potential antimicrobial action of TAM. Coronaviruses are enveloped positive-sense RNA nucleic acid viruses that have club-like spikes, characterized by a distinctive replication strategy;they are round and sometimes pleomorphic in shape. Coronavirus disease 2019 (COVID-19) is regarding the new genera of coronaviredia that appeared for the first time in Wuhan, China, in early December 2019. Due to the continuous spread of the novel COVID-19 with the exponential rise in death numbers, new therapeutic development is urgent;in general, there are no specific antiviral drugs or vaccines for 2019-nCoV. Hence, this review will discuss the most recent information about the antiviral action of TAM against COVID-19 infection by trying to give a deep understanding of major properties, mechanisms of action, immune system responses, and antimicrobial efficiency of TAM that is regarding the promising way to treat COVID-19 novel infection. The current review may serve as an impetus for researchers working in the field of medical microbiology, vaccination, and antiviral drug design. The review also rationally reports and critically analyzes the available knowledge by focusing and mentioning future steps and strategies trying to find appropriate solutions regarding challenges in COVID-19 management by TAM utilization. © 2020 Biomedical and Biotechnology Research Journal (BBRJ) ;Published by Wolters Kluwer . Medknow.